Concomitant use of drugs with neurotoxic, hematotoxic, or cardiotoxic effects may increase the toxicity of interferons. Long-term effects of ACTIMMUNE on fertility are not known. ACTIMMUNE or nursing should be discontinued dependent on the importance of the drug to the mother Use of ACTIMMUNE by lactating mothers is not recommended. ACTIMMUNE should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Renal toxicity has been reported in patients receiving ACTIMMUNE Monitor renal function regularly when administering ACTIMMUNE in patients with severe renal insufficiency accumulation of interferon gamma-1b may occur with repeated administration. If severe hepatic enzyme elevations develop, ACTIMMUNE dosage should be modified Patients begun on ACTIMMUNE before age 1 year should receive monthly assessments of liver function. Myelosuppression, or receiving other potentially myelosuppressive agents consider dose reduction or discontinuation of therapy. 
Seizure disorders or compromised central nervous system function reduce dose or discontinue.
Pre-existing cardiac conditions, including ischemia, congestive heart failure, or arrhythmia.ACTIMMUNE should be used with caution in patients with:.coli derived products, or any component of the product In patients who develop or have known hypersensitivity to interferon-gamma, E.IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS For delaying time to disease progression in patients with severe, malignant osteopetrosis.For reducing the frequency and severity of serious infections associated with Chronic Granulomatous Disease.ACTIMMUNE ® (Interferon gamma-1b) is indicated:
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